Training and Further Education:

• Editorial training fellowship, Journal of Interventional Cardiac Electrophysiology, Springer Nature, 2023-2024

• Basic Life Support and Automated External Difibrillation (BLS/AED), ERC European Resuscitation Council

• Advanced Life Support (ALS), ERC European Resuscitation Council

Areas of Concentration/ Research Interests:

Cardiology, Cardiac Arrhythmias, Atrial Fibrillation, Syncope, Sudden Cardiac Death, Biostatistics

List of publications:

1. Doundoulakis I, Nedios S, Zafeiropoulos S, Vitolo M, Della Rocca DG, Kordalis A, et al. Atrial fibrillation burden: Stepping beyond the categorical characterization. Heart rhythm. 2024.
2. Doundoulakis I, Marcon L, Pannone L, Della Rocca DG, Del Monte A, Sorgente A, et al. Empirical slow pathway ablation in patients with paroxysmal palpitations and pounding in the neck: A 15-year follow-up. Heart rhythm. 2024.
3. Doundoulakis I, Pannone L, Chiotis S, Della Rocca DG, Sorgente A, Tsioufis P, et al. SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis. Heart rhythm. 2024.
4. Doundoulakis I, Chiotis S, Pannone L, Della Rocca DG, Sorgente A, Kordalis A, et al. Catheter ablation as an adjunctive therapy to ICD implantation in Brugada syndrome. European heart journal Quality of care & clinical outcomes. 2024.
5. Doundoulakis I, Pannone L, Cespón-Fernández M, Eltsov I, Chierchia GB, de Asmundis C, et al. A large footprint focal catheter toggling between pulsed field and radiofrequency energy: first clinical experience for ventricular tachycardia ablation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2024;26(7).
6. Zafeiropoulos S, Doundoulakis I, Bekiaridou A, Farmakis IT, Papadopoulos GE, Coleman KM, et al. Rhythm vs Rate Control Strategy for Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials. JACC Clinical electrophysiology. 2024.
7. Del Monte A, Della Rocca DG, Pannone L, Vetta G, Doundoulakis I, Cespón Fernández M, et al. Coronary Vasospasm During Isthmus Pulsed Field Ablation With Wide Area Focal Catheter. Circulation Arrhythmia and electrophysiology. 2024:e012923.
8. Del Monte A, Della Rocca DG, Pannone L, Vetta G, Cespón Fernández M, Marcon L, et al. Pulsed field ablation of the right superior pulmonary vein prevents vagal responses via anterior right ganglionated plexus modulation. Heart rhythm. 2024.
9. Menè R, Boveda S, Della Rocca DG, Sousonis V, Vetta G, Zeriouh S, et al. Efficacy of Intravenous Nitrates for the Prevention of Coronary Artery Spasm During Pulsed Field Ablation of the Mitral Isthmus. Circulation Arrhythmia and electrophysiology. 2024;17(1):e012426.
10. Pannone L, Bisignani A, Osei R, Gauthey A, Sorgente A, Monaco C, et al. Correlations of ventricular fibrillation and monomorphic ventricular tachycardia with SCN5A mutations and other clinical variables in Brugada syndrome. Heart rhythm. 2024.
11. Doundoulakis I, Pannone L, Brugada P, de Asmundis C. Author’s Reply to – Revisiting the prognostic role of SCN5A in Brugada syndrome. Heart rhythm. 2024.
12. Kartas A, Papazoglou AS, Moysidis DV, Despotopoulos S, Baroutidou A, Kosmidis D, et al. Use of apixaban in adults with congenital heart disease and atrial arrhythmias: The PROTECT-AR study. International journal of cardiology. 2024;406:131993.
13. Nakasone K, Tanaka K, Del Monte A, Della Rocca DG, Pannone L, Mouram S, et al. Distance-dependent neuromodulation effect during thermal ablation for atrial fibrillation. Journal of cardiovascular electrophysiology. 2024.
14. Scacciavillani R, Koliastasis L, Doundoulakis I, Chiotis S, Kordalis A, Narducci ML, et al. Remote Monitoring of Cardiac Implantable Electronic Devices in Very Elderly Patients: Advantages and Specific Problems. Journal of cardiovascular development and disease. 2024;11(7).
15. Tsiachris D, Argyriou N, Tsioufis P, Antoniou CK, Laina A, Oikonomou G, et al. Aggressive Rhythm Control Strategy in Atrial Fibrillation Patients Presenting at the Emergency Department: The HEROMEDICUS Study Design and Initial Results. Journal of cardiovascular development and disease. 2024;11(4).
16. Koliastasis L, Doundoulakis I, Xaplanteris P. Bending the Reluctance of No Pretreatment With P2Y(12) Inhibitors in ST-Segment Elevation Myocardial Infarction. JACC Cardiovascular interventions. 2024;17(6):822.
17. Alkhodari M, Khandoker AH, Jelinek HF, Karlas A, Soulaidopoulos S, Arsenos P, et al. Circadian assessment of heart failure using explainable deep learning and novel multi-parameter polar images. Computer methods and programs in biomedicine. 2024;248:108107.
18. Al Younis SM, Hadjileontiadis LJ, Khandoker AH, Stefanini C, Soulaidopoulos S, Arsenos P, et al. Prediction of heart failure patients with distinct left ventricular ejection fraction levels using circadian ECG features and machine learning. PloS one. 2024;19(5):e0302639.
19. Della Rocca DG, Marcon L, Magnocavallo M, Menè R, Pannone L, Mohanty S, et al. Pulsed electric field, cryoballoon, and radiofrequency for paroxysmal atrial fibrillation ablation: a propensity score-matched comparison. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2023;26(1).

20. Doundoulakis I, Tsiachris D, Kordalis A, Koliastasis L, Soulaidopoulos S, Arsenos P, et al. Management of Patients With Unexplained Syncope: Derivation and Validation of a Simplified 2-Step Diagnostic Approach. Journal of the American Heart Association. 2023;12(22):e031659.

21. Zafeiropoulos S, Doundoulakis I, Farmakis IT, Miyara S, Giannis D, Giannakoulas G, et al. Autonomic Neuromodulation for Atrial Fibrillation Following Cardiac Surgery: JACC Review Topic of the Week. Journal of the American College of Cardiology. 2022;79(7):682-94.
22. Economou FI, Doundoulakis I, Kalamakidou I, Koliastasis L, Soulaidopoulos S, Samara M, et al. Prevention of Radial Artery Spasm With Transdermal Glyceryl Trinitrate Patches: The NURSE-TTS Randomized Study. JACC Cardiovascular interventions. 2023;16(3):365-7.
23. Doundoulakis I, Tsioufis K, Gatzoulis KA. Letter by Doundoulakis et al Regarding Article, “Programmed Ventricular Stimulation as Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy”. Circulation. 2023;147(22):1714.
24. Zafeiropoulos S, Farmakis IT, Milioglou I, Doundoulakis I, Gorodeski EZ, Konstantinides SV, et al. Pharmacological Treatments in Heart Failure With Mildly Reduced and Preserved Ejection Fraction: Systematic Review and Network Meta-Analysis. JACC Heart failure. 2023.
25. Tsiachris D, Antoniou CK, Doundoulakis I, Manolakou P, Sougiannis D, Kordalis A, et al. Best Practice Guide for Cryoballoon Ablation in Atrial Fibrillation: The Compilation Experience of More than 1000 Procedures. Journal of cardiovascular development and disease. 2023;10(2).
26. Doundoulakis I, Tsiachris D, Kordalis A, Soulaidopoulos S, Arsenos P, Xintarakou A, et al. Management of Patients With Unexplained Syncope and Bundle Branch Block: Predictive Factors of Recurrent Syncope. Cureus. 2023;15(3):e35827.
27. Tsiachris D, Doundoulakis I, Kordalis A, Antoniou CK, Tsioufis K. Superior vena cava isolation with pulsed field ablation in the presence of defibrillator leads. Journal of arrhythmia. 2023;39(3):483-5.
28. Tsioufis P, Tsiachris D, Doundoulakis I, Kordalis A, Antoniou CK, Vlachakis PK, et al. Rationale and Design of a Randomized Controlled Clinical Trial on the Safety and Efficacy of Flecainide versus Amiodarone in the Cardioversion of Atrial Fibrillation at the Emergency Department in Patients with Coronary Artery Disease (FLECA-ED). Journal of clinical medicine. 2023;12(12).
29. Chiotis S, Doundoulakis I, Pagkalidou E, Piperis C, Zafeiropoulos S, Botis M, et al. Total Atrial Conduction Time as a Predictor of Atrial Fibrillation Recurrence: A Systematic Review and Meta-Analysis. Cardiology in review. 2023.
30. Farmakis IT, Baroutidou A, Patsiou V, Arvanitaki A, Doundoulakis I, Hobohm L, et al. Contribution of pressure and flow changes to resistance reduction after pulmonary arterial hypertension treatment: a meta-analysis of 3898 patients. ERJ open research. 2024;10(1).
31. Kostopoulos G, Doundoulakis I, Toulis KA, Karagiannis T, Tsapas A, Haidich AB. Prognostic models for heart failure in patients with type 2 diabetes: a systematic review and meta-analysis. Heart (British Cardiac Society). 2023;109(19):1436-42.
32. Milaras N, Dourvas P, Doundoulakis I, Sotiriou Z, Nevras V, Xintarakou A, et al. Noninvasive electrocardiographic risk factors for sudden cardiac death in dilated ca rdiomyopathy: is ambulatory electrocardiography still relevant? Heart failure reviews. 2023;28(4):865-78.
33. Soulaidopoulos S, Xintarakou A, Vogiatzakis N, Doundoulakis I, Arsenos P, Archontakis S, et al. Atrial fibrillation: An early marker of ventricular myocardial dysfunction. Kardiologia polska. 2023.
34. Vlachakis PK, Tsiachris D, Doundoulakis I, Tsioufis P, Kordalis A, Botis M, et al. Therapeutic inertia in rhythm control strategies in hospitalized patients with fibrillation: Insights from Hellenic Cardiorenal Morbidity Snapshot (HECMOS) study. Journal of cardiology. 2023.
35. Tsiartas E, Samaras A, Papazoglou AS, Kartas A, Moysidis DV, Gemousakakis E, et al. Changes in CHA(2)DS(2)-VASc score and risk of ischemic stroke among patients with atrial fibrillation. Heart and vessels. 2023;38(10):1267-76.

36. Halapas A, Koliastasis L, Doundoulakis I, Antoniou CK, Stefanadis C, Tsiachris D. Transcatheter Aortic Valve Implantation and Conduction Disturbances: Focus on Clinical Implications. Journal of cardiovascular development and disease. 2023;10(11).

37. Tsiachris D, Botis M, Doundoulakis I, Bartsioka LI, Tsioufis P, Kordalis A, et al. Electrocardiographic Characteristics, Identification, and Management of Frequent Premature Ventricular Contractions. Diagnostics (Basel, Switzerland). 2023;13(19).

38. Tsiachris D, Papakonstantinou PE, Doundoulakis I, Tsioufis P, Botis M, Dimitriadis K, et al. Anticoagulation Status and Left Atrial Appendage Occlusion Indications in Hospitalized Cardiology Patients with Atrial Fibrillation: A Hellenic Cardiorenal Morbidity Snapshot (HECMOS) Sub-Study. Medicina (Kaunas, Lithuania). 2023;59(10).

39. Dimitriadis K, Soulaidopoulos S, Doundoulakis I, Iliakis P, Tsiachris D, Tsioufis P, et al. A network meta-analysis of the antithrombotic strategies in patients with atrial fibrillation and percutaneous coronary interventions: Focus on bleeding. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2023;73:69-72.
40. Doundoulakis I, Farmakis IT, Theodoridis X, Konstantelos A, Christoglou M, Kotzakioulafi E, et al. Effects of dietary interventions on cardiovascular outcomes: a network meta-analysis. Nutrition reviews. 2023.
41. Pagkalidou E, Doundoulakis I, Apostolidou-Kiouti F, Bougioukas KI, Papadopoulos K, Tsapas A, et al. An overview of systematic reviews on imaging tests for diagnosis of pulmonary embolism applying different network meta-analytic methods. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2023.
42. Leontsinis I, Farmakis D, Avramidis D, Andrikou E, Valatsou A, Gartzonikas E, et al. Cardiorenal multimorbidity in hospitalized cardiology patients: The Hellenic Cardiorenal Morbidity Snapshot (HECMOS) study. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2023.
43. Goulas I, Evripidou K, Doundoulakis I, Kollios K, Nika T, Chainoglou A, et al. Prevalence of masked hypertension and its association with left ventricular hypertrophy in children and young adults with chronic kidney disease: a systematic review and meta-analysis. Journal of hypertension. 2023;41(5):699-707.
44. Koliastasis L, Doundoulakis I, Rychter J, Zembala M, Ninios V, Ninios I, et al. Transcatheter aortic valve implantation with self-expanding valves and the impact of balloon predilatation: the DIRECT II trial. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2023.
45. Tzikos G, Doundoulakis I, Doutsini S, Adamidou F, Zafeiropoulos S, Koliastasis L, et al. Effect of Parathyroidectomy on Left Ventricular Mass Index in Patients With Primary Hyperparathyroidism. Cureus. 2023;15(1):e33429.
46. Al Younis SM, Hadjileontiadis LJ, Al Shehhi AM, Stefanini C, Alkhodari M, Soulaidopoulos S, et al. Investigating automated regression models for estimating left ventricular ejection fraction levels in heart failure patients using circadian ECG features. PloS one. 2023;18(12):e0295653.
47. Alkhodari M, Khandoker AH, Jelinek HF, Karlas A, Soulaidopoulos S, Arsenos P, et al. Circadian assessment of heart failure using explainable deep learning and novel multi-parameter polar images. Computer methods and programs in biomedicine. 2024;248:108107.
48. Tsiachris D, Antoniou CK, Doundoulakis I, Manolakou P, Kordalis A, Konstantinou D, et al. Three-dimensional electroanatomically guided slow pathway elimination is associated with procedural improvements and clinical benefit in atrioventricular node reentrant tachycardia patients. Journal of arrhythmia. 2022;38(6):1035-41.
49. Seo J, Li W, Safiriyu I, Kharawala A, Nagraj S, Tahir A, et al. A Meta-Analysis on the Impact of High BMI in Patients Undergoing Transcatheter Aortic Valve Replacement. Journal of cardiovascular development and disease. 2022;9(11).
50. Baroutidou A, Kartas A, Papazoglou AS, Kosmidis D, Moysidis DV, Otountzidis N, et al. Association of Health Status Metrics with Clinical Outcomes in Patients with Adult Congenital Heart Disease and Atrial Arrhythmias. Journal of clinical medicine. 2022;11(20).
51. Tsiachris D, Doundoulakis I, Antoniou CK, Pagkalidou E, Zafeiropoulos S, Kordalis A, et al. Effectiveness and safety of a time to isolation strategy of cryoballoon ablation of atrial fibrillation: A systematic review and meta-analysis. Journal of cardiovascular electrophysiology. 2022.
52. Archontakis S, Oikonomou EK, Sideris K, Laina A, Tirovola D, Paraskevopoulou D, et al. Safety of same-day discharge versus overnight stay strategy following cardiac device implantations: a high-volume single-centre experience. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2022:1-11.
53. Papazoglou AS, Farmakis IT, Zafeiropoulos S, Moysidis DV, Karagiannidis E, Stalikas N, et al. Angiographic severity in acute coronary syndrome patients with and without standard modifiable risk factors. Frontiers in cardiovascular medicine. 2022;9:934946.
54. Tsimos KP, Korantzopoulos P, Arsenos P, Doundoulakis I, Tsiachris D, Antoniou CK, et al. Association of non-invasive electrocardiographic risk factors with left ventricular systolic function in post-myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE-EF study. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2022;27(5):e12946.
55. Antza C, Farmakis I, Doundoulakis I, Akrivos E, Stalikas N, Zafeiropoulos S, et al. Reproducibility of masked hypertension and office-based hypertension: a systematic review and meta-analysis. Journal of hypertension. 2022;40(6):1053-9.
56. Koliastasis L, Doundoulakis I, Kokkinidis DG, Milkas A, Drakopoulou M, Benetos G, et al. TAVI with the ACURATE neo transcatheter heart valve in special populations: A systematic review. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2022.
57. Doundoulakis I, Arsenos P, Tsiachris D, Kordalis A, Antoniou CK, Tsioufis K, et al. To the Editor – Are we close to a major impact on prevention of sudden cardiac death among coronary artery disease patients? Heart rhythm O2. 2022;3(2):218.
58. Farmakis IT, Zafeiropoulos S, Doundoulakis I, Papazoglou AS, Karagiannidis E, Giannakoulas G. Temporal trends in the efficacy of revascularization in stable ischaemic heart disease: A cumulative meta-analysis. American journal of preventive cardiology. 2022;10:100340.
59. Arsenos P, Gatzoulis KA, Laina A, Doundoulakis I, Soulaidopoulos S, Kordalis A, et al. QT interval extracted from 30-minute short resting Holter ECG recordings predicts mortality in heart failure. Journal of electrocardiology. 2022;72:109-14.
60. Farmakis IT, Zafeiropoulos S, Doundoulakis I, Pagiantza A, Karagiannidis E, Moysidis DV, et al. Comparative efficacy and safety of oral P2Y(12) inhibitors after non-ST-elevation acute coronary syndromes: a network meta-analysis. Open heart. 2022;9(1).
61. Koliastasis L, Doundoulakis I, Kokkinidis DG, Milkas A, Kostopoulos G, Drakopoulou M, et al. Study Level Meta-Analysis of TAVI with the ACURATE neo Self-expanding Transcatheter Heart Valve. Cardiology in review. 2022.

62. Doundoulakis I, Gatzoulis KA, Arsenos P, Dilaveris P, Tsiachris D, Antoniou CK, et al. Permanent pacemaker implantation in unexplained syncope patients with electrophysiology study-proven atrioventricular node disease. Hellenic journal of cardiology. 2022.

63. Pagkalidou E, Anastasilakis DA, Kokkali S, Doundoulakis I, Tsapas A, Dardavessis T, et al. Reporting completeness in abstracts of systematic reviews of diagnostic test accuracy studies in cardiovascular diseases is suboptimal. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2022.
64. Tsiachris D, Doundoulakis I, Tsioufis P, Pagkalidou E, Antoniou CK, Zafeiropoulos SM, et al. Reappraising the role of class Ic antiarrhythmics in atrial fibrillation. European journal of clinical pharmacology. 2022.
65. Kartas A, Papazoglou AS, Kosmidis D, Moysidis DV, Baroutidou A, Doundoulakis I, et al. The Adult Congenital Heart Disease Anatomic and Physiological Classification: Associations with Clinical Outcomes in Patients with Atrial Arrhythmias. Diagnostics (Basel, Switzerland). 2022;12(2).
66. Tsiachris D, Doundoulakis I, Tsioufis K. Pharmacologic Cardioversion of Paroxysmal Atrial Fibrillation in the Emergency Department in the Novel Anticoagulants’ Era. Cardiovascular drugs and therapy. 2022.
67. Stalikas N, Doundoulakis I, Karagiannidis E, Sianos G, Giannakoulas G. P-wave dispersion as a marker of atrial cardiopathy in embolic stroke of undetermined source. Author’s reply. European journal of internal medicine. 2022.

68. Stalikas N, Doundoulakis I, Karagiannidis E, Kartas A, Gavriilaki M, Sofidis G, et al. Prevalence of markers of atrial cardiomyopathy in embolic stroke of undetermined source: A systematic review. European journal of internal medicine. 2022.

69. Samaras A, Vrana E, Kartas A, Moysidis DV, Papazoglou AS, Doundoulakis I, et al. Prognostic implications of valvular heart disease in patients with non-valvular atrial fibrillation. BMC cardiovascular disorders. 2021;21(1):453.

70. Alkhodari M, Jelinek HF, Karlas A, Soulaidopoulos S, Arsenos P, Doundoulakis I, et al. Deep Learning Predicts Heart Failure With Preserved, Mid-Range, and Reduced Left Ventricular Ejection Fraction From Patient Clinical Profiles. Frontiers in cardiovascular medicine. 2021;8:755968.

71. Goulas I, Farmakis I, Doundoulakis I, Antza C, Kollios K, Economou M, et al. Comparison of the 2017 American Academy of Pediatrics with the fourth report and the 2016 European Society of Hypertension guidelines for the diagnosis of hypertension and the detection of left ventricular hypertrophy in children and adolescents: a systematic review and meta-analysis. Journal of hypertension. 2021.

72. Doundoulakis I, Tsiachris D, Gatzoulis KA, Stefanadis C, Tsioufis K. Atrial high rate episodes as a marker of atrial cardiomyopathy: In the quest of the Holy Grail. European journal of internal medicine. 2021.

73. Doundoulakis I, Gavriilaki M, Tsiachris D, Arsenos P, Antoniou CK, Dimou S, et al. Atrial High-Rate Episodes in Patients with Devices Without a History of Atrial Fibrillation: a Systematic Review and Meta-analysis. Cardiovascular drugs and therapy. 2021.

74. Doundoulakis I, Gatzoulis KA, Arsenos P, Dilaveris P, Skiadas I, Tsiachris D, et al. Permanent pacemaker implantation in unexplained syncope patients with borderline sinus bradycardia and electrophysiology study-proven sinus node disease. Journal of arrhythmia. 2021;37(1):189-95.

75. Kostopoulos G, Doundoulakis I, Antza C, Bouras E, Nirantharakumar K, Tsiachris D, et al. Incident atrial fibrillation in patients with differentiated thyroid cancer: a meta-analysis. Endocrine-related cancer. 2021;28(5):325-35.

76. Laina A, Gatzoulis KA, Soulaidopoulos S, Arsenos P, Doundoulakis I, Tsiachris D, et al. Time to Reconsider Risk Stratification in Dilated Cardiomyopathy. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2021.

77. Antza C, Doundoulakis I, Stabouli S, Kotsis V. American, European and international hypertension guidelines: Time to shake hands? International Journal of Cardiology Hypertension. 2021;8:100075.

78. Farmakis IT, Pyrgidis N, Doundoulakis I, Mykoniatis I, Akrivos E, Giannakoulas G. Effects of Major Antihypertensive Drug Classes on Erectile Function: a Network Meta-analysis. Cardiovascular drugs and therapy. 2021.

79. Oikonomidou AC, Doundoulakis I, Antza C, Kalopitas G, Dardavessis T, Chourdakis M. Evaluation of subclinical cardiac damage in biopsy-proven nonalcoholic fatty liver disease: a systematic review and meta-analysis. Annals of gastroenterology. 2021;34(3):424-30.

80. Soulaidopoulos S, Arsenos P, Doundoulakis I, Tsiachris D, Antoniou CK, Dilaveris P, et al. Syncope associated with supraventricular tachycardia: Diagnostic role of implantable loop recorders. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2021:e12850.

81. Farmakis IT, Vazakidis P, Doundoulakis I, Arvanitaki A, Zafeiropoulos S, Boutou A, et al. Haemodynamic effects of PAH-targeted therapies in pulmonary hypertension due to lung disease: A systematic review and meta-analysis. Pulmonary pharmacology & therapeutics. 2021;68:102036.

82. Giannakoulas G, Doundoulakis I. Cardiovascular Disease Risk Prediction Models and Scores. Current pharmaceutical design. 2021;27(10):1231.

83. Farmakis I, Doundoulakis I, Zafeiropoulos S, Pagiantza A, Apostolidou-Kiouti F, Kourti O, et al. Comparative efficacy and safety of oral P2Y12 inhibitors for patients with chronic kidney disease and acute coronary syndrome: Α network meta-analysis. Hellenic journal of cardiology. 2021.

84. Tsiachris D, Doundoulakis I, Pagkalidou E, Kordalis A, Deftereos S, Gatzoulis KA, et al. Pharmacologic Cardioversion in Patients with Paroxysmal Atrial Fibrillation: A Network Meta-Analysis. Cardiovascular drugs and therapy. 2021.

85. Zafeiropoulos S, Pagiantza A, Doundoulakis I, Stalikas N, Farmakis I, Samaras A, et al. Cardio-protective Effects of Glucagon-like Peptide-1 Receptor Agonists: An Overview of Systematic Reviews and Publication Overlap. Current pharmaceutical design. 2021.

86. Kyriakoulis KG, Kokkinidis DG, Kyprianou IA, Papanastasiou CA, Archontakis-Barakakis P, Doundoulakis I, et al. Venous thromboembolism in the era of COVID-19. Phlebology. 2021;36(2):91-9.

87. Gatzoulis KA, Arsenos P, Antoniou CK, Dilaveris P, Sideris S, Tsiachris D, et al. Signal-averaged electrocardiogram findings among right ventricular arrhythmogenic cardiomyopathy (ARVC) patients: Do they have a place in ARVC management? International journal of cardiology. 2021;322:175.

88. Karantoumanis I, Doundoulakis I, Zafeiropoulos S, Oikonomou K, Makridis P, Pliakos C, et al. Atrial conduction time associated predictors of recurrent atrial fibrillation. The international journal of cardiovascular imaging. 2021.

89. Kartas A, Doundoulakis I, Ntiloudi D, Koutsakis A, Kosmidis D, Rampidis G, et al. Rationale and design of a prospective, observational, multicentre study on the safety and efficacy of apixaban for the prevention of thromboembolism in adults with congenital heart disease and atrial arrhythmias: the PROTECT-AR study. BMJ open. 2020;10(9):e038012.

90. Arsenos P, Gatzoulis KA, Doundoulakis I, Dilaveris P, Antoniou CK, Stergios S, et al. Arrhythmic risk stratification in heart failure mid-range ejection fraction patients with a non-invasive guiding to programmed ventricular stimulation two-step approach. Journal of arrhythmia. 2020;36(5):890-

91. Doundoulakis I, Antza C, Karvounis H, Giannakoulas G. Non-Vitamin K Antagonist Oral Anticoagulants in Pulmonary Embolism: An Overview of Systematic Reviews. Current pharmaceutical design. 2020;26(23):2686-91.

92. Papanastasiou A, Morsi-Yeroyannis A, Karagiannidis E, Kartas A, Doundoulakis I, Karvounis H, et al. Association of anticoagulant-related bleeding events with cancer detection in atrial fibrillation: A systematic review and meta-analysis. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2020.

93. Farmakis I, Doundoulakis I, Pagiantza A, Zafeiropoulos S, Antza C, Karvounis H, et al. Lipoprotein(a) reduction with proprotein convertase subtilisin/kexin type 9 inhibitors: a systematic review and meta-analysis. Journal of cardiovascular pharmacology. 2020.

94. Solomou E, Gatzoulis KA, Skiadas I, Doundoulakis I, Arsenos P, Dilaveris P, et al. Upgrade to cardiac resynchronization therapy difibrillator device of a pacemaker-dependent patient with end-stage hypertrophic cardiomyopathy. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. 2020;61(1):65-7.

95. Stalikas N, Doundoulakis I, Karagiannidis E, Bouras E, Kartas A, Frogoudaki A, et al. Non-Vitamin K Oral Anticoagulants in Adults with Congenital Heart Disease: A Systematic Review. Journal of clinical medicine. 2020;9(6).

96. Samaras A, Doundoulakis I, Antza C, Zafeiropoulos S, Farmakis I, Tzikas A. Comparative Analysis of Risk Stratification Scores in Atrial Fibrillation. Current pharmaceutical design. 2020.

97. Antza C, Vazakidis P, Doundoulakis I, Bouras E, Haidich AB, Stabouli S, et al. Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta-analysis. Journal of clinical hypertension (Greenwich, Conn). 2020;22(5):802-11.

98. Antza C, Dimou C, Doundoulakis I, Akrivos E, Stabouli S, Haidich AB, et al. The flipside of hydralazine in pregnancy: A systematic review and meta-analysis. Pregnancy hypertension. 2020;19:177-86.

99. Antza C, Doundoulakis I, Akrivos E, Stabouli S, Chrysaidou K, Gidaris D, et al. Estimated arterial stiffness and prediction of vascular aging: The rising of a new era. Current pharmaceutical design. 2020.

100. Antza C, Doundoulakis I, Kostopoulos G, Stabouli S, Kotsis V. Τhe European and American guidelines in the detection of hypertension phenotypes: The no-deal under the light of clinical practice. European journal of preventive cardiology. 2020:2047487320935559.

101. Antza C, Doundoulakis I, Kostopoulos G, Stabouli S, Kotsis V. Τhe European and American guidelines in the detection of hypertension phenotypes: The no-deal under the light of clinical practice. European journal of preventive cardiology. 2020.

102. Kostopoulos G, Antza C, Doundoulakis I, Toulis KA. Risk Models and Scores of Cardiovascular Disease in Patients with Diabetes Mellitus. Current pharmaceutical design. 2020.

103. Natsis M, Antza C, Doundoulakis I, Stabouli S, Kotsis V. Hypertension in Obesity: Novel Insights. Current hypertension reviews. 2020;16(1):30-6.

104. Antza C, Doundoulakis I, Akrivos E, Economou F, Vazakidis P, Haidich AB, et al. Non-vitamin K oral anticoagulants in nonvalvular atrial fibrillation: a network meta-analysis. Scandinavian cardiovascular journal : SCJ. 2019;53(2):48-54.

105. Antza C, Doundoulakis I, Stabouli S, Tziomalos K, Kotsis V. Masked hypertensives: A disguised arterial stiffness population. Journal of clinical hypertension (Greenwich, Conn). 2019;21(10):1473-80.

106. Antza C, Nirantharakumar K, Doundoulakis I, Tahrani AA, Toulis KA. The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date. Drug design, development and therapy. 2019;13:2985-96.

107. Dimou C, Antza C, Akrivos E, Doundoulakis I, Stabouli S, Haidich AB, et al. A systematic review and network meta-analysis of the comparative efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in hypertension. Journal of human hypertension. 2019;33(3):188-201.

108. Doundoulakis I, Antza C, Kotsis V, Giannakoulas G. A gut feeling about children’s exposure to hypertensive disorders of pregnancy in utero. European journal of preventive cardiology. 2019;26(16):1715-7.

109. Giannopoulou EZ, Doundoulakis I, Antza C, Christoforidis A, Haidich AB, Kotsis V, et al. Subclinical arterial damage in children and adolescents with type 1 diabetes: A systematic review and meta-analysis. Pediatric diabetes. 2019;20(6):668-77.

110. Stabouli S, Nika T, Kollios K, Antza C, Doundoulakis I, Kotsis V. Performance of simplified tables for high blood pressure screening in a European pediatric population. Journal of hypertension. 2019;37(5):917-22.

111. Doundoulakis I, Antza C, Apostolidou-Kiouti F, Akrivos E, Karvounis H, Kotsis V, et al. Overview of Systematic Reviews of Non-Vitamin K Oral Anticoagulants in Atrial Fibrillation. Circulation Cardiovascular quality and outcomes. 2018;11(12):e004769.

112. Antza C, Doundoulakis I, Akrivos E, Stabouli S, Trakatelli C, Doumas M, et al. Early Vascular Aging Risk Assessment From Ambulatory Blood Pressure Monitoring: The Early Vascular Aging Ambulatory Score. American journal of hypertension. 2018;31(11):1197-204.

113. Antza C, Doundoulakis I, Stabouli S, Kotsis V. Comparison Among Recommendations for the Management of Arterial Hypertension Issued by Last US, Canadian, British and European Guidelines. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2018;25(1):9-16.

114. Antza C, Doundoulakis I, Natsis M, Kotsis V. Treatment of Early Vascular Ageing. Current pharmaceutical design. 2018;24(37):4385-90.

115. Antza C, Stabouli S, Natsis M, Doundoulakis I, Kotsis V. Obesity-Induced Hypertension: New Insights. Current pharmaceutical design. 2017;23(31):4620-5.

116. Kotsis V, Antza C, Doundoulakis I, Stabouli S. Markers of Early Vascular Ageing. Current pharmaceutical design. 2017;23(22):3200-4.

Webinars (presenter role)/Training sessions (trainer role):

• Journal club for the working group of electrophysiology and pacing (Hellenic Society of Cardiology). 09/ 2024

Title: ADVENT trial. PFA vs Thermal energy

• Journal club for the working group of electrophysiology and pacing (Hellenic Society of Cardiology). 03/2024

Title: NOAH-AFNET 6 trial. ARTESiA trial. Meta-analysis of these two RCTs

Scholarly Activities

Core Organising Committee Member of the following congresses:

• Hellenic cardiology congress of Drama, 2022

• Hellenic cardiology congress of Drama, 2023

Conference Presentations:

Invited speaker

• Unexplained syncope, Hellenic cardiology congress of Drama, 20-22 December 2024, Drama, Greece.

• Pulsed Field Ablation, Hellenic cardiology congress of Drama, 20-22 December 2024, Drama, Greece.

• Pulsed ElectRic FiEld versus Cryoballoon to Treat Paroxysmal Atrial Fibrillation (PERFECT-PAF) randomized trial: a periprocedural clinical and economic analysis, 10ου Workshop Arrhythmias and Pacemaker, 22-24 November, Athens, Greece.

• Cathater ablation as a first line treatment in paroxysmal atrial fibrillation, CardioBeans 2024, 21-23 November, Thessaloniki, Greece.

• Anticoagulation in patients with stroke of unknown etiology, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Promising novel PFA systems (PulseSelect, Volt and novel catheters), Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

Oral Sessions

• Pulsed field versus hybrid ablation in patients with long standing persistent atrial fibrillation: a propensity score matched comparison, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Spontaneous Type 1 ECG and arrhythmic risk in Brugada Syndrome: a systematic review and meta-analysis of adjusted and unadjusted time-to-event data, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• SCN1A gene variants and arrhythmic risk in Brugada Syndrome: a systematic review and meta-analysis, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Effectiveness and safety of electrical cardioversion in the emergency department, HEROMEDICUS study, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Effectiveness and safety of advanced rhythm control strategy in the emergency department, HEROMEDICUS study, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Irrigated radiofrequency catheter ablation for AVNRT, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Age-related and location-related analysis for premature ventricular contraction, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Long term follow-up for premature ventricular contraction ablation, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Association of superior vena cava isolation with improved outcomes in atrial fibrillation ablation, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

Advisory (students supervised, theses directed etc):

Member of the Supervisory team of 1 PhD:

1.Pagkalidou E.: Development and comparison of statistical methodology in network meta-analysis of diagnostic test accuracy studies applied to cardiovascular diseases. Medical School, Aristotle University of Thessaloniki, Greece

Member of the Supervisory team of 3 MScs:

1.Oflidis E.: Pulmonary venous isolation plus posterior wall isolation vs pulmonary venous isolation alone in patients with persistent atrial fibrillation, A systematic review and meta-analysis. Aristotle University of Thessaloniki

2.Tzioutzia S.: Factors associated with the risk of death or intubation in hospitalized patients with COVID-19 at the Florina General Hospital : A retrospective cohort study. Medical School, Aristotle University of Thessaloniki

3.Salonis G.A.: Predictive Modeling for Unexplained Syncope: A Cox-Regression Approach. Medical School, Aristotle University of Thessaloniki

Books Chapters, Edited, Written or Translated:

Book Chapters:

• Chapter 11: “Syncope”, in “Cardiology” by Giannakoulas G., Rotonta Publishers Ltd, 2022

• Chapter 12: “Sudden Cardiac Death”, in “Cardiology” by Giannakoulas G., Rotonta Publishers Ltd, 2022

• Cardiac electrophysiology and pacing (EP) fellow, Heart Rhythm Management Center, UZ Brussels, Brussels, Belgium, 2024-present

• Resident of cardiology, UZ Brussels, Brussels, Belgium, 2023-2024

• Resident of cardiology, First Department of Cardiology, National and Kapodistrian University, 2021-2023

• Resident of cardiology, 424 General Military Hospital, Thessaloniki, Greece,2018-2021

• Lieutenant Doctor, 71st Airbone Brigade, Medical Director in a military camp 2014 – 2018.

• Foundation and Training at 401 General Military Hospital, Athens, Greece, 2013-2014.

• Postgraduate program in Cardiac Electrophysiology and Pacing, Vrije University Brussels, Belgium, 2024-present

• Second PhD (c) in cardiology/electrophysiology, Vrije University Brussels, Belgium, Thesis title: “Causes and prevention of sudden cardiac death”, 2024-present

• Doctor of Philosophy (PhD) in Cardiology/Electrophysiology, National and Kapodistrian University of Athens, Greece, Thesis title: “The importance of electrophysiologic study in unexplained syncope” 2019-2022

• Master of Science (MSc), Medical Research Methodology, School of Medicine, Aristotle University of Thessaloniki, Greece (grade: 9/10), 2015-2017

• Doctor of Medicine Degree (MD), Medical School of Thessaloniki, Aristotle University of Thessaloniki, (grade: 8/10), 2007-2013

• Greek Military School of Combat Support Officers (SSAS), Combat abilities combined with medical practice. (Military service obligations fulfilled) 2007-2013

Secondary Education:

Gymnasium and Lyceum of Drama, Greece (Honorary Diploma, Ministry of Education and Religion award for excellent performance during secondary education for six consecutive years, grade:19.8/20, 2000-2006

Core Organising Committee Member of the following congresses:

• Hellenic cardiology congress of Drama, 2022

• Hellenic cardiology congress of Drama, 2023

Conference Presentations:

Invited speaker

• Unexplained syncope, Hellenic cardiology congress of Drama, 20-22 December 2024, Drama, Greece.

• Pulsed Field Ablation, Hellenic cardiology congress of Drama, 20-22 December 2024, Drama, Greece.

• Pulsed ElectRic FiEld versus Cryoballoon to Treat Paroxysmal Atrial Fibrillation (PERFECT-PAF) randomized trial: a periprocedural clinical and economic analysis, 10ου Workshop Arrhythmias and Pacemaker, 22-24 November, Athens, Greece.

• Cathater ablation as a first line treatment in paroxysmal atrial fibrillation, CardioBeans 2024, 21-23 November, Thessaloniki, Greece.

• Anticoagulation in patients with stroke of unknown etiology, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Promising novel PFA systems (PulseSelect, Volt and novel catheters), Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

Oral Sessions

• Pulsed field versus hybrid ablation in patients with long standing persistent atrial fibrillation: a propensity score matched comparison, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• Spontaneous Type 1 ECG and arrhythmic risk in Brugada Syndrome: a systematic review and meta-analysis of adjusted and unadjusted time-to-event data, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

• • Effectiveness and safety of electrical cardioversion in the emergency department, HEROMEDICUS study, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  • Effectiveness and safety of advanced rhythm control strategy in the emergency department, HEROMEDICUS study, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  • Irrigated radiofrequency catheter ablation for AVNRT, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  • Age-related and location-related analysis for premature ventricular contraction, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  • Long term follow-up for premature ventricular contraction ablation, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  • Association of superior vena cava isolation with improved outcomes in atrial fibrillation ablation, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

  SCN1A gene variants and arrhythmic risk in Brugada Syndrome: a systematic review and meta-analysis, Panhellenic Congress of Cardiology, 31-02 November 2024, Hersonissos, Greece.

Training and Further Education:

 Editorial training fellowship, Journal of Interventional Cardiac Electrophysiology, Springer
Nature, 2023-2024
 Basic Life Support and Automated External Difibrillation (BLS/AED), ERC European
Resuscitation Council
 Advanced Life Support (ALS), ERC European Resuscitation Council
Areas of Concentration/ Research Interests:
Cardiology, Cardiac Arrhythmias, Atrial Fibrillation, Syncope, Sudden Cardiac Death,
Biostatistics

• Award for best submission in the context of the Hellenic Society of Cardiology Congress 2022 for the work titled: “Management of patients with unexplained syncope and bundle branch block: Predictive factors of recurrent syncope”.

• Award for best submission in the context of the Hellenic Society of Cardiology Congress 203 for the work titled: “Safety and efficacy of apixaban in the prevention of thromboembolic events in adults with congenital heart disease and atrial arrhythmia”.

Advisory (students supervised, theses directed etc):

Member of the Supervisory team of 1 PhD:

1.Pagkalidou E.: Development and comparison of statistical methodology in network meta-analysis of diagnostic test accuracy studies applied to cardiovascular diseases. Medical School, Aristotle University of Thessaloniki, Greece

Member of the Supervisory team of 3 MScs:

1.Oflidis E.: Pulmonary venous isolation plus posterior wall isolation vs pulmonary venous isolation alone in patients with persistent atrial fibrillation, A systematic review and meta-analysis. Aristotle University of Thessaloniki

2.Tzioutzia S.: Factors associated with the risk of death or intubation in hospitalized patients with COVID-19 at the Florina General Hospital : A retrospective cohort study. Medical School, Aristotle University of Thessaloniki

3.Salonis G.A.: Predictive Modeling for Unexplained Syncope: A Cox-Regression Approach. Medical School, Aristotle University of Thessaloniki

Contact Numbers: +30-694-6002830

E-mail address: doudougiannis@gmail.com

PersonalWebsite:https://www.linkedin.com/in/ioannis-doundoulakis-a50b9247/